No one can escape from the aggressive predatory Xenomorphs. With this in mind, a crippled Predator spaceship crash-lands on the dense forest of Gunnison, Colorado, right after the Antarctic bloodshed in Alien vs. Predator (2004). As a result, a vicious Predalien hybrid, along with myriads of Stage 1 Xenomorphs, or Face-huggers, scatter in all directions, infecting everyone unfortunate enough to cross their path. Once more, the Earth is a battlefield, as both extraterrestrial species fight for supremacy. Now, with the humans stuck in the middle of a brutal face-off, Sheriff Eddie Morales must protect the city with a handful of residents. However, motivation alone is not enough. Can a team of inexperienced defenders ensure the fate of humankind?